There are currently no approved antidotes for GHB overdose. At high doses, the drug can cause amnesia, drowsiness and depressed breathing. However, GHB prescriptions are limited due to its high potential for abuse as a club and date-rape drug. GHB is approved for a number of clinical uses, including the treatment of narcolepsy, a chronic sleep disorder, and alcoholism. Previous studies completed by the UB researchers found that the NSAIDs ibuprofen and ketoprofen also affected the movement of GHB in the body. The study, completed in animal models, was published in Biopharmaceutics & Drug Disposition. The research found that treatment with diclofenac after taking GHB led to decreased concentrations of GHB in the brain and an improved respiration. – Diclofenac and other non‐steroidal anti‐inflammatory drugs (NSAIDs) may limit the passage of gamma hydroxybutyric acid (a narcolepsy medication and illicit party drug commonly known as GHB) to the brain, decreasing the potential for fatal overdose, according to a University at Buffalo study.
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